2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-156385
    SCO-PEG8-NHS 2143968-68-5
    SCO-PEG8-NHS SCO is a PROTAC linker and belongs to the PEG class. SCO-PEG8-NHS SCO contains SCO and NHS esters that can be covalently bound to amino groups, respectively. SCO is often used to react with amino acid residues of proteins or peptides, particularly lysine.
    SCO-PEG8-NHS
  • HY-141093
    Pyrene-PEG5-alcohol 1817735-44-6
    Pyrene-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pyrene-PEG5-alcohol
  • HY-141406
    m-PEG5-2-methylacrylate 48074-75-5
    m-PEG5-2-methylacrylate is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG5-2-methylacrylate
  • HY-141159
    TCO-PEG4-acid 1802913-21-8
    TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG4-acid
  • HY-141334
    Lipoamido-PEG12-acid 2407442-47-9
    Lipoamido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Lipoamido-PEG12-acid
  • HY-140253
    N-(Amino-PEG3)-N-bis(PEG3-Boc) 2055042-62-9
    N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Amino-PEG3)-N-bis(PEG3-Boc)
  • HY-140508
    m-PEG12-NH-C2-acid 1949843-39-3
    m-PEG12-NH-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-NH-C2-acid
  • HY-118411S1
    5-Ethynyl-2'-deoxyuridine-13C2 1610530-35-2
    5-Ethynyl-2'-deoxyuridine-13C2 (EdU-13C2) is the 13C-labeled 5-Ethynyl-2'-deoxyuridine (HY-118411). 5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-Ethynyl-2'-deoxyuridine-<sup>13</sup>C<sub>2</sub>
  • HY-134746
    Hexaethylene glycol dimethyl ether 1072-40-8
    Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hexaethylene glycol dimethyl ether
  • HY-W096157
    I-PEG5-OH 1883516-31-1
    I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    I-PEG5-OH
  • HY-134681
    Fmoc-NH-PEG5-NH-Boc
    Fmoc-NH-PEG5-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG5-NH-Boc
  • HY-130568
    Mal-PEG1-PFP ester 1807530-08-0
    Mal-PEG1-PFP ester is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG1-PFP ester
  • HY-140951
    m-PEG12-DSPE
    m-PEG12-DSPE is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-DSPE
  • HY-133371
    DBCO-NHCO-C4-NHS ester
    DBCO-NHCO-C4-NHS ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-C4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-C4-NHS ester
  • HY-140226
    m-PEG10-amine 1383658-09-0
    m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG10-amine
  • HY-140440
    Fmoc-aminooxy-PEG4-acid 1895922-70-9
    Fmoc-aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-aminooxy-PEG4-acid
  • HY-140594
    m-PEG3-S-PEG4-propargyl 2055040-85-0
    m-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-S-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    m-PEG3-S-PEG4-propargyl
  • HY-140597
    Propargyl-PEG4-S-PEG4-acid 2055041-20-6
    Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-S-PEG4-acid
  • HY-141224
    m-PEG23-alcohol
    m-PEG23-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG23-alcohol
  • HY-144082
    C18-PEG13-acid
    C18-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    C18-PEG13-acid
PROTAC Linkers Isoform Comparison

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